Scientists at the University of Edinburgh have developed AI algorithms to discover drugs that could combat ageing. The researchers used machine learning models to analyze large amounts of biological data and identify compounds that could potentially extend lifespan and improve health in older adults.
The team leveraged a database of over 1,000 small molecules that had shown positive effects on age-related diseases in previous studies. They then applied a series of machine learning models to identify additional compounds with similar properties, ultimately identifying 11 promising candidates.
One of the most promising compounds identified by the team is called rapamycin, which has been shown in previous studies to extend lifespan in mice. However, the drug has not yet been approved for use in humans due to potential side effects.
To further validate their findings, the researchers tested the 11 compounds on roundworms, which are often used as a model organism in ageing research. They found that several of the compounds extended the worms’ lifespan and improved their overall health.
Dr João Pedro de Magalhães, one of the study’s lead authors, said:
“This work demonstrates the power of AI to accelerate drug discovery and lead to new treatments for ageing and age-related diseases. Our findings suggest that several of these compounds may have therapeutic potential and warrant further investigation.”
The researchers hope that their work will pave the way for the development of new drugs that can help to combat the effects of ageing and improve quality of life in older adults. With the global population aging rapidly, there is an urgent need for new treatments that can address the unique challenges faced by older individuals.
AI Algorithms Conclusion
In addition to developing new drugs, the team also plans to use their AI algorithms to investigate the mechanisms underlying ageing and age-related diseases. By gaining a deeper understanding of these processes, they hope to identify new targets for drug development and contribute to the development of more effective therapies for ageing-related conditions.
Overall, this research highlights the potential of AI to revolutionize drug discovery and accelerate the development of new treatments for some of the most pressing health challenges facing society today.